IDENTIFICATION OF NEURAL CREST AND GLIAL ENHANCERS AT THE MOUSE SOX10 LOCUS THROUGH TRANSGENESIS IN ZEBRAFISH.

Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish.

Sox10 is a dynamically regulated transcription factor gene that is essential for the development of neural crest-derived and oligodendroglial populations.Developmental genes often require multiple regulatory sequences that integrate discrete and overlapping functions to coordinate their expression.To identify Sox10 cis-regulatory elements, we integ

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A copper switch for inducing CRISPR/Cas9-based transcriptional activation tightly regulates gene expression in Nicotiana benthamiana

Abstract Background CRISPR-based programmable transcriptional activators (PTAs) are used in plants for rewiring gene networks.Better tuning of their activity in a time and dose-dependent manner should allow precise control of gene expression.Here, we report the optimization of a Copper Inducible system called CI-switch for conditional FPV Antennas

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